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Emagene Lab - Functional and transcriptional genomics of lymphoid malignancies  

Emagene Lab - Functional and transcriptional genomics of lymphoid malignancies


Staff Emagene LabThe activity of the research group headed by Prof. Antonino Neri has always been aimed at the identification and characterization of genetic lesions in B-cells and T-cells lymphoid malignancies. In particular, the group has got a world-wide recognized expertise in the field of multiple myeloma (MM) and plasma cell dyscrasia biology. A specific interest is represented by the molecular pathogenesis of MM. In that, the research laboratory has used molecular approaches to identify chromosomal translocations involving the immunoglobulin heavy chain locus that may deregulate genes likely implicated in myelomagenesis. Neri and colleagues, in 1990s, for the first time described the t(4;14)(p16.3;q32) translocation involving two putative oncogenes. More recently, with the acquisition of platforms for global genomic analysis (microarray technology and then next-generation sequencing) and bioinformatics skills, the laboratory has contributed to the characterization of transcriptome, miRNome, genome and methylome in normal and malignant plasma cells and in other lymphoproliferative disorders, mainly chronic lymphocytic leukemia. Currently, the research group is involved in the transcriptional and functional characterization of the small and long non-coding RNA fraction in myeloma. The current projects of the research group supervised by Prof. Neri are also addressed to the investigation of the functional and clinical relevance of RNA splicing dysregulation in MM, and the biological and clinical monitoring of plasma cell dyscrasias through the genotyping of circulating cell-free tumor DNA. 
The laboratory has received continuous financial support from AIRC since 1989.
For a list of selected relevant or recent publications, look at pdf in this page .
Antonino Neri
Antonino Neri
Associate professor
Lab header
NomeQualificaArea ricercaCVFoto

Rita Lucia Nobili

Senior researchers

Projects managementCurriculum VitaeRita Lucia Nobili

Domenica Ronchetti

Senior researcher

Projects managementCurriculum VitaeDomenica Ronchetti
Luca AgnelliSenior researcherBioinformaticianCurriculum VitaeLuca Agnelli
Katia TodoertiSenior researcherMicroarray unitCurriculum VitaeKatia Todoerti
Marta LionettiSenior researcherNGS unitCurriculum Vitae 
Elisa TaianaSenior researcherCellular biology and functional studiesCurriculum VitaeElisa Taiana
Sonia FabrisSenior researcherCytogenetics unitCurriculum Vitae 
Gabriella CiceriSenior researcherCytogenetics unitCurriculum Vitae 
Ilaria SilvestrisSenior researcherCytogenetics unitCurriculum Vitae 

Silvia Lonati

Senior researcherCytogenetics unitCurriculum VitaeSilvia Lonati

Marzia Barbieri

Senior researcherCytogenetics unitCurriculum VitaeMarzia Barbieri

Martina Manzoni


NGS unitCurriculum Vitae

Vanessa Favasuli

PhD studentStudentCurriculum VitaeVanessa Favasuli

Francesca Pelizzoni

Lab technicianMolecular biologyCurriculum Vitae 

Simone Salerio

Lab techincianMolecular biologyCurriculum Vitae 
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